Classification of familial adenomatous polyposis

Familial adenomatous polyposis includes classical familial adenomatous polyposis (classical familial adenomatous polyposis). CFAP) and attenuated familial adenomatous polyposis (AFAP).

The number of colorectal adenomatous polyps of CFAP was more than 1000, the age of onset was before 20 years old, the average age of carcinogenesis was 34 years old, and the cancer rate was 100%.

CFAP family members because at puberty onset before the age of 20, usually suggest starting from the age of 10 ~ 15, line 1 times every 1 ~ 3 year colonoscopy screening, once found polyps, the line 1 time every year a colonoscopy parallel polyps resection, in order to reduce the polyp load, delay due to overload or colorectal polyp surgery time, so as to prolong the lifetime.

The number of colorectal adenomatous polyps in AFAP is less than 100, the age of onset is 30-50 years old, the average age of carcinogenesis is 50-55 years old, and the cancer rate is 69%. AFAP family members are advised to have a colonoscopy every 2 years, starting between the ages of 18 and 20.

FAP patients with polyposis-related symptoms such as rectal bleeding, diarrhea, or mucinous stools should undergo colonoscopy regardless of age, especially patients with structural pathogenic mutations of codon 1309, who are at higher risk of cancer.